In the landscape of modern medicine, the most challenging cases often converge at the intersection of different specialized conditions. For women living with systemic autoimmune conditions, the path from diagnosis to life-saving interventions like organ transplantation is full of invisible risks.

In complex cases, multidisciplinary collaboration becomes the primary tool for survival. Our series explored these high-stakes scenarios, demonstrating how data-guided medicine transforms complex female health journeys from precarious to stable.

The Challenge: SLE often carries a distinct serologic signature that can evolve into severe complications. It is a chronic, multisystem autoimmune disease and because it can affect nearly any organ system, it is often referred to as "the great imitator," presenting with highly variable clinical features that can range from mild to life-threatening. It predominantly affects women of childbearing age, with a female-to-male ratio of approximately 9:1.
Check out our interview on Autoimmunity Expert:
Serena De Lucia, Product Manager Autoimmunity, Italy
Moderator: Daniele Ielo, Clinical Scientific Manager EEMEA

The Challenge: Antiphospholipid Syndrome (APS) is a cornerstone of complexity in women's health, demanding a constant balance between preventing recurrent thrombosis and managing bleeding risks during procedures. Specialized testing is essential for tailoring lifelong anticoagulation strategies and monitoring patients through high-risk clinical events. Secondary APS has a prevalence of female to male ratio often cited at 7:1, mirroring the strong female bias of the underlying SLE.
Check out our interview on Hemostasis Expert:
Kerrie Jaskal, Senior Product Manager, Worldwide Hemostasis Marketing Reagent Team
Moderator: Sara Sampietro, Product Manager Hemostasis EEMEA

The Challenge: In women with a history of autoimmune diseases compatible blood is rarely straightforward. The diagnosis with Positive direct antiglobulin tests (DAT) of warm autoantibody interference require extended immunohematology workups to ensure safe transfusion without triggering further hemolysis. Women account for approximately 60% to 67% of all AIHA cases.
Check out our interview on Transfusion Expert:
Dr. Silvia Giulia Ferrari, Director Worldwide Scientific Affairs, Transfusion
Moderator: Désirée Agosta, Marketing Manager Transfusion EEMEA

The Challenge: For women with end-stage organ failure and high sensitization from prior HLA exposure, transplantation is a significant challenge. Success relies on high-resolution HLA typing and Single Antigen Bead (SAB) testing to map donor-specific antibodies (DSA) and guide peri-transplant immunosuppression. In cohorts of transplant recipients with SLE, women represent approximately 81% to 87% of the population.
Check out our interview on Transplant Expert:
Christine Heylen, Director International Commercial Scientific Affairs, Transplant
Moderator: Frank Blanco Pérez, Product Manager Transplant EEMEA

The Challenge: During major surgery, women with complex histories often face a "coagulation paradox": a high risk for thrombosis paired with unexpected diffuse bleeding. Instead of empiric blood product transfusion, near-patient testing that help provide real-time data on fibrinogen levels and clot firmness, allow for targeted, life-saving bleeding management in critical care.
Check out our interview on Acute Care Diagnostics Expert:
Ariadna Quijada, Product Manager for ROTEM, Iberia
Moderator: Arianna Strazzella, Product Manager ACDx EEMEA

In the most complex clinical scenarios, our collective expertise does more than provide data—it provides a path forward. By bringing together specialized diagnostics in Hemostasis, Acute Care, Autoimmunity, Transfusion, and Transplant, we are uniquely positioned to Power Patient Care when it matters most.

Let’s continue making a difference together—raising awareness, refining outcomes, and ensuring that even the most "invisible" risks are seen and managed.